Glycogen Synthase Kinase 3 and 3 Mediate a Glucose-Sensitive Antiapoptotic Signaling Pathway To Stabilize Mcl-1
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چکیده
Published Ahead of Print 19 March 2007. 10.1128/MCB.00153-07. 2007, 27(12):4328. DOI: Mol. Cell. Biol. Tannishtha Reya and Jeffrey C. Rathmell Wofford, Leah N. Dimascio, Olga Ilkayeva, Ameeta Kelekar, A. E. Herman, Sarah R. Jacobs, Heather L. Wieman, Jessica Yuxing Zhao, Brian J. Altman, Jonathan L. Coloff, Catherine Signaling Pathway To Stabilize Mcl-1 Mediate a Glucose-Sensitive Antiapoptotic β and 3 α Glycogen Synthase Kinase 3
منابع مشابه
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Myeloid cell leukemia-1 (Mcl-1), an antiapoptotic Bcl-2 family member, is overexpressed in many types of human cancer and associates with cell immortalization, malignant transformation, and chemoresistance. Glycogen synthase kinase-3beta (GSK-3beta), a key component of the Wnt signaling pathway, is involved in multiple physiologic processes such as protein synthesis, tumorigenesis, and apoptosi...
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Mcl-1 is a member of the Bcl2-related protein family that is a critical mediator of cell survival. Exposure of cells to stress causes inhibition of Mcl-1 mRNA translation and rapid destruction of Mcl-1 protein by proteasomal degradation mediated by a phosphodegron created by glycogen synthase kinase 3 (GSK3) phosphorylation of Mcl-1. Here we demonstrate that prior phosphorylation of Mcl-1 by th...
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Glycogen synthase kinase-3β (GSK-3β) regulates the sequential activation of caspase-2 and caspase-8 before mitochondrial apoptosis. Here, we report the regulation of Mcl-1 destabilization and cathepsin D-regulated caspase-8 activation by GSK-3β and caspase-2. Treatment with either the ceramide analogue C2-ceramide or the topoisomerase II inhibitor etoposide sequentially induced lysosomal membra...
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The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance of Mcl-1 expression is an important determinant of drug resistance in cancer. Phosphorylation at Thr 163 in the PEST region, stimulated by 12-O-tet...
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